Immunoregulatory T Cell Function in Multiple Myeloma
نویسندگان
چکیده
منابع مشابه
Defective immunoregulatory T-cell function in chronic lymphocytic leukemia.
Chronic lymphocytic leukemia (CIL) of B-cell origin results in the malignant proliferation of small immunoglobulinbearing lymphocytes. There is currently a controversy in the literature regarding both the ability of this leukemic population to differentiate into mature plasma cells. as well as the ability of apparently normal T cells from these patients to regulate allogeneic B-cell differentia...
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Background: Multiple myeloma (MM) is a malignant plasma cell proliferative disorder with limited immunotherapy treatment because of T cell dysfunction. Objective: To investigate the immunomodulatory function of bone marrow mesenchymal stromal cells (MM-BMSCs) on CD8+ T cells. Methods: Proliferation and cytotoxicity were detected by c...
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This literature review presents the most recent developments in the management of multiple myeloma, which is characterized by the presence of abnormal plasma cells (myeloma cells) that accumulate into the bone marrow. Aspects related to pathophysiology, clinical manifestations, laboratory, study and treatment are described. These pieces of information are necessary to accomplish a better ...
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The functional maturity of T and B lymphocyte populations from human newborns was evaluated using a reverse hemolytic plaque assay to detect immunoglobulin-secreting cells generated in in vitro cultures stimulated with pokeweed mitogen (PWM), a T cell-dependent polyclonal activator, and the Epstein-Barr virus (EBV), a T cell-independent B cell activator. Cord blood lymphocytes failed to produce...
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High-dose treatment (HDT) with autologous stem cell transplantation (ASCT) has been shown to increase survival and time to progression in multiple myeloma (IMM) compared with conventional chemotherapy. In the French IFM90-study [1], 200 patients were randomised to receive prolonged standard treatment with i.v. combination chemotherapy, or a short phase by induction treatment with the same regim...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1981
ISSN: 0021-9738
DOI: 10.1172/jci110095